This case describes the growth of a biotechnology company as it shifts from a service research organization to an integrated human therapeutic company. The case maps the management changes from 1982-1998 as the company responds to volatile market pressures. Survivor Scios can be used to illustrate the challenges of shifting strategies in a research intensive organization. In addition it can be used to point up the different management styles needed at different stages of a company's life cycle. Finally the case demonstrates the unique issues of product development in a biotechnology firm.